Tweelingfamilieonderzoek

Speurtocht naar genetische varianten

Het NTR neemt via verschillende consortia deel aan grote onderzoeken waarbinnen wordt gezocht naar genetische varianten voor erfelijk bepaalde complexe aandoeningen en eigenschappen. Dit zijn onder
meer ENGAGE (European Network for Genetic and Genomic Epidemiology; zie links hieronder), EAGLE (EArly Genetics and Lifecourse Epidemiology), BBMRI (Biobanking and Biomolecular

Resources Research Infrastructure), CMSB (Centre for Medical Systems Biology), NCA (Neuroscience Campus Amsterdam), EMGO+ (Extramuraal Geneeskundig Onderzoek), PGC (Psychiatric GWAS Consortium) en genomEUtwin.

Links

http://www.euengage.org/index.html

http://www.bbmri.nl/

http://www.bbmri.eu/

http://www.cmsb.nl/home/index.php

https://pgc.unc.edu/index.php

http://www.neurosciencecampus-amsterdam.nl/en/index.asp

http://www.emgo.nl/

http://www.genomeutwin.org/
http://wiki.genepi.org.au/display/EAGLE/EAGLE

Sinds 2009 verscheen er een groot aantal publicaties waarin genen zijn gevonden voor o.a. diabetes, rookverslaving, depressie, geboortegewicht en gewicht later in het leven.

Deze publicaties zijn te vinden onder de knop Verslaggeving.

Beijsterveldt, van et al. Influence of candidate genes on Attention Problems in children: a longitudinal study. Behav Genet 41(1):155-164, 2011
Breen et al. Failure to replicate association of 3p21.1 with susceptibility to major depression. Nat Genet 43(1): 1-3, 2011
Bosker et al. Poor replication of candidate genes for major depressive disorder using genome-wide association data. Mol Psychiatry 16(5):516-532, 2011
Deelen et al. Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell 10(4):686-698, 2011
Dehghan et al. Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-reactive protein levels. Circulation 22;123(7):731-8, 2011
Demirkan et al. Genetic architecture of circulating lipid levels. Eur J Hum Genet 19, 813–819, 2011
Demirkan et al. Genetic risk profiles for depression and anxiety in adult and elderly cohorts. Mol Psychiatry 16(7):773-83, 2011
Kilpeläinen et al. Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals. Am J Clin Nutr 93(4):851-60, 2011
Liu et al. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry 16(1):2-4, 2011
Ligthart et al. Meta-analysis of genome-wide association for migraine in six population-based European cohorts. Eur J Hum Genet 19(8):901-7, 2011
Maugeri et al. LPAR1 and ITGA4 regulate peripheral blood monocyte counts. Human Mutation 32(8):873-6, 2011
Pergadia et al. A 3p26-3p25 Genetic Linkage Finding for DSM-IV Major Depression in Heavy Smoking Families. Am J Psychiatry 168:8, 848-852, 2011
Saviouk et al. ADHD in Dutch Adults: Heritability and linkage study. Am J Med Genet B Neuropsychiatr Genet 156(3):352-62, 2011
Schumann et al. Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc
Natl Acad Sci USA 108(17):7119-24, 2011
Speliotes et al. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet 7(3)
e1001324, 2011
Slof-Op 't Landt et al. Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting. Genes Brain Behav 10: 236–243, 2011
Bartels et al. Heritability and genome-wide linkage scan of subjective happiness. Twin Res Hum Genet. 13(2) 135-142, 2010
Beek, van et al. Associations between ADH gene variants and alcohol phenotypes in Dutch adults. Twin Res Hum Genet 13(1):30-42, 2010
Beekman et al. GWAS-identified disease risk alleles do not compromise human longevity. Proc Natl Acad Sci U S A. 107(42):18046-9, 2010
Dupuis et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42(2):105-16, 2010. Erratum in: 42(5):464
Elks et al. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet. 42(12):1077-85, 2010
Freathy et al. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet 42(5):430-5, 2010
Hart, 't et al. Combined risk allele score of eight type 2 diabetes genes is associated with reduced first phase glucose stimulated insulin secretion during hyperglycaemic clamps.
Diabetes 59(1):287-92, 2010
Heid et al. GIANT consortium . Meta-analysis identifies 13 novel loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Nat Genet. 42(11):949-60, 2010
Heni et al. The impact of genetic variation in the G6PC2 gene on insulin secretion depends on glycemia. J Clin Endocrinol Metab. 95(12):E479-84, 2010
Lango Allen et al on behalf of GIANT consortium. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature, 467(7317):832-838, 2010
Lind et al. A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. Twin Res Hum Genet 13(1):10-29, 2010
Middeldorp et al. Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes? Genes, Brain, Behavior 9(6):808-816, 2010
Middeldorp et al. The serotonin transporter gene (5-HTTLPR) and life events: no interaction on neuroticism and anxious depressive symptoms. Twin Res Hum Genet 13(6):544-9,
2010
Middeldorp et al. An association between EPAC-1 gene variants and anxiety and depression in two independent samples. Am J Med Genet B Neuropsychiatr Genet. 153B(1):214-9,
2010
Moor, de et al. Meta-analysis of genome-wide association studies for personality. Mol Psychiatry 2010, in press
Nettleton et al. Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort
studies. Diabetes Care, 33(12):2684-91
Painter et al. A genome wide linkage scan for dizygotic twinning in 525 families of mothers of dizygotic twins. Hum Reprod. 25(6):1569-80, 2010
Perlis et al. Genome-wide Association Study of Suicide Attempts in Mood Disorder Patients, The Am J Psychiatry 167(12):1499-507, 2010
Petrides et al. Relationships between trait emotional intelligence and the Big Five in the Netherlands. Personality Individ Differences. 48, 906–910, 2010
Polderman et al. No effect of classroom sharing on educational achievement in twins: a prospective, longitudinal cohort study. Journal of Epidemiology and Community Health 64:36– 40, 2010
Reiling et al. The association of mitochondrial content with prevalent and incident type 2 diabetes. The Journal of Clinical Endocrinology & Metabolism 95(4):1909-15, 2010
Simonis-Bik et al. Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A and MTNR1B affect different aspects of pancreatic beta
cell function.Diabetes, 59(1):293-301, 2010
Soranzo et al. Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways. Diabetes 59(12): 3229-3239, 2010
Speliotes et al. GIANT consortium. Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index. Nat Genet 42(11):937-48, 2010
Terracciano et al. Genome-wide association scan for five major dimensions of personality. Molecular Psychiatry, 15, 647–656 , 2010
Teslovich et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466(7307): 707-13, 2010
Thorgeirsson et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet 42(5):448-53, 2010
The Tobacco and Genetics Consortium. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet 42(5):441-7, 2010
Wray et al. Genome-wide association study of major depressive disorder: New results, meta-analysis, and lessons learned. Mol Psychiatry 2010, open access
Aulchenko et al. for the ENGAGE Consortium. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 41(1):47-55, 2009
Benyamin et al. Common variants in TMPRSS6 are associated with iron status and erythrocyte volume. Nat Genet 41(11):1173-5, 2009
Bochdanovits et al. Joint reanalysis of 29 correlated SNPs supports the role of PCLO/Piccolo as a causal risk factor for major depressive disorder. Mol Psychiatry 14(7):650-2, 2009
Estrada et al. A genome-wide association study of northwestern Europeans involves the CNP signaling pathway in the etiology of human height variation. Hum Mol Genet:3516-24, 2009
Ferreira et al. Sequence variants in three loci influence monocyte counts and erythrocyte volume. Am J Hum Genet 85(5):745-9, 2009
McEvoy et al. Geographical structure and differential natural selection amongst North European populations. Genome Res 19(5):804-14, 2009
Moor, de et al. Genome-wide association study of leisure-time exercise behavior in Dutch and American adults. Med Sci Sports Exerc 41(10): 1887-1895, 2009
Pardo et al. Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap-CEU populations. Eur J Hum Genet 17(6):802-10, 2009
Prokopenko et al. Variants in the melatonin receptor 1B gene (MTNR1B) influence fasting glucose levels, Nat Genet 41(1):77-81, 2009
Sullivan et al. Genome wide association for major depressive disorder: A possible role for the presynaptic protein piccolo. Mol Psychiatry 14:359–75, 2009
Vink et al. Genome-wide association study of smoking initiation and current smoking. Am J Hum Genet 84(3):367-79, 2009