Speurtocht naar genetische
varianten
Het NTR neemt via verschillende consortia
deel aan grote onderzoeken waarbinnen wordt gezocht naar genetische
varianten voor erfelijk bepaalde complexe aandoeningen en eigenschappen. Dit
zijn onder
meer ENGAGE (European Network for Genetic and Genomic Epidemiology;
zie links onderaan de pagina), EAGLE (EArly Genetics and Lifecourse
Epidemiology), BBMRI (Biobanking
and Biomolecular
Resources Research Infrastructure), CMSB (Centre for Medical Systems Biology), NCA (Neuroscience Campus Amsterdam), EMGO+ (Extramuraal Geneeskundig Onderzoek), PGC (Psychiatric GWAS Consortium) en genomEUtwin.
Sinds 2009 verscheen een groot aantal publicaties waarin genen zijn gevonden voor o.a. diabetes, rookverslaving, depressie, geboortegewicht en gewicht later in het leven.
Aulchenko et al. for the ENGAGE Consortium. Loci influencing lipid
levels and coronary heart disease risk in 16 European population
cohorts. Nat Genet 41(1):47-55, 2009
Beek et al. Associations between ADH gene variants and alcohol
phenotypes in Dutch adults. Twin Res Hum Genet 13(1):30-42, 2010
Benyamin et al. Common variants in TMPRSS6 are associated with iron
status and erythrocyte volume. Nat Genet
41(11):1173-5,
2009
Bochdanovits et al. Joint reanalysis of 29 correlated SNPs supports
the role of PCLO/Piccolo as a causal risk factor for major depressive
disorder. Mol Psychiatry 14(7):650-2, 2009
Bosker et al. Poor replication of candidate genes for major
depressive disorder using genome-wide association data. Mol
Psychiatry 2010, epub
Demirkan et al. Genetic risk profiles for depression and anxiety in
adult and elderly cohorts. Mol Psychiatry 2010, epub
Dupuis J.
New genetic loci implicated in fasting glucose homeostasis and their
impact on type 2 diabetes risk.
Nat Genet 42(2):105-16, 2010. Erratum in: 42(5):464
Estrada et al. A genome-wide association study of northwestern
Europeans involves the CNP signaling pathway in the etiology of human
height variation. Hum Mol Genet:3516-24, 2009
Ferreira et al. Sequence variants in three loci influence monocyte
counts and erythrocyte volume. Am J Hum Genet
85(5):745-9, 2009
Freathy et al.
Variants in ADCY5 and near CCNL1 are associated with fetal growth and
birth weight.
Nat Genet 42(5):430-5, 2010
GIANT consortium. Hundreds of variants clustered in genomic loci and
biological pathways affect human height. Nature, 2010, in press
't Hart LM,
et al.
Combined
risk allele score of eight type 2 diabetes genes is associated with
reduced first phase glucose stimulated insulin secretion during
hyperglycaemic clamps.
Diabetes
59(1):287-92,
2010
Lind et al. A genomewide
association study of nicotine and alcohol dependence in Australian and
Dutch populations. Twin Res Hum Genet 13(1):10-29, 2010
Liu Y et al. Meta-analysis of genome-wide association data of bipolar
disorder and major depressive disorder. Mol Psych 2010, epub
McEvoy et al. Geographical structure and differential natural
selection amongst North European populations. Genome Res
19(5):804-14, 2009
Middeldorp et al. Anxiety and depression in children and adults:
influence of serotonergic and neurotrophic genes? Genes, Brain,
Behavior, 2010, epub
Moor et al. Genome-wide association study of leisure-time exercise
behavior in Dutch and American adults.
Med Sci Sports Exerc
41(10): 1887-1895, 2009
Pardo et al. Global similarity with local differences in linkage
disequilibrium between the Dutch and HapMap-CEU populations. Eur J
Hum Genet 17(6):802-10, 2009
Perlis RH et al. Genome-wide Association Study of Suicide Attempts in
Mood Disorder Patients. The American Journal of Psychiatry, 2010, in
press
Prokopenko et al. Variants in the melatonin receptor 1B gene (MTNR1B)
influence fasting glucose levels, Nat Genet 41(1):77-81, 2009
Simonis-Bik et al. Gene variants in the novel type 2 diabetes loci
CDC123/CAMK1D, THADA, ADAMTS9, BCL11A and MTNR1B affect different
aspects of pancreatic beta cell function.
Diabetes,
59(1):293-301,
2010
Sullivan et al. Genome wide association for
major depressive disorder: A possible role for the presynaptic protein
piccolo. Mol Psychiatry 14:359–75, 2009
Terracciano et al.
Genome-wide association scan for five major dimensions of personality.
Molecular Psychiatry,
15, 647–656
, 2010
Teslovich et al. Biological, clinical and population relevance of 95
loci for blood lipids. Nature 466(7307): 707-13, 2010
Thorgeirsson et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6
affect smoking behavior. Nat Genet 42(5):448-53, 2010
The Tobacco and Genetics
Consortium. Genome-wide meta-analyses identify multiple loci
associated with smoking behavior. Nat Genet 42(5):441-7, 2010
Vink et al. Genome-wide association study of smoking initiation and current smoking. Am J Hum Genet 84(3):367-79, 2009
Links
http://www.euengage.org/index.html
http://www.cmsb.nl/home/index.php
http://www.neurosciencecampus-amsterdam.nl/en/index.asp
http://www.genomeutwin.org/
http://wiki.genepi.org.au/display/EAGLE/EAGLE